2022 Division III football schedule Greenville
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 7-3 | .700 | 5-1 | .833 | Won 4 | 5-1 | 2-2 | 0-0 |
| Date | Opponent | Result | Time/Status | Links |
| Sep. 3 | at Millikin | L, 28-14 | Final | BX |
| Sep. 10 | Rockford | W, 40-30 | Final | BX |
| Sep. 17 | Manchester | W, 49-22 | Final | BX RC |
| Sep. 24 | Olivet | L, 63-7 | Final | BX |
| Oct. 1 | Martin Luther * | W, 30-27 | Final | BX |
| Oct. 8 | at Northwestern (Minn.) * | L, 41-35 | Final | BX |
| Oct. 15 | Westminster (Mo.) * | W, 52-0 | Final | BX |
| Oct. 29 | at Crown * | W, 48-6 | Final | BX |
| Nov. 5 | Finlandia * | W, 45-7 | Final | BX |
| Nov. 12 | at Minnesota-Morris * | W, 43-25 | Final | BX |
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