2022 Division III football schedule Hampden-Sydney
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 5-5 | .500 | 4-3 | .571 | Lost 2 | 3-2 | 2-3 | 0-0 |
| Date | Opponent | Result | Time/Status | Links |
| Sep. 3 | at Wabash | L, 52-48 | Final | BX |
| Sep. 10 | Widener | L, 31-27 | Final | BX RC |
| Sep. 17 | Greensboro | W, 70-28 | Final | BX RC |
| Oct. 1 | at Bridgewater * | L, 27-17 | Final | BX RC RC |
| Oct. 8 | at Ferrum * | W, 35-16 | Final | BX RC |
| Oct. 15 | Averett * | W, 37-26 | Final | BX RC |
| Oct. 22 | at Washington and Lee * | W, 44-43 | Final - OT | BX RC |
| Oct. 29 | Guilford * | W, 28-21 | Final | BX RC |
| Nov. 5 | at Shenandoah * | L, 23-7 | Final | BX RC |
| Nov. 12 | Randolph-Macon * | L, 38-17 | Final | BX RC RC |
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