2000 Schedule Muskingum
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 4-6 | .400 | 3-6 | .333 | Lost 1 | 3-2 | 1-4 | 0-0 |
| Date | Opponent | Result | Time/Status | Links |
| Sep. 2 | Mount St. Joseph | W, 42-14 | Final | |
| Sep. 16 | at Ohio Northern * | L, 49-0 | Final | |
| Sep. 24 | Wilmington * | L, 21-14 | Final | |
| Sep. 30 | Marietta * | W, 31-29 | Final | |
| Oct. 7 | at Capital * | W, 38-35 | Final | |
| Oct. 14 | John Carroll * | L, 41-3 | Final | |
| Oct. 21 | at Baldwin-Wallace * | L, 52-7 | Final | |
| Oct. 28 | at Mount Union * | L, 62-7 | Final | |
| Nov. 4 | Heidelberg * | W, 45-35 | Final | |
| Nov. 11 | at Otterbein * | L, 30-26 | Final | |
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