2000 Schedule Defiance
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 7-3 | .700 | 4-2 | .667 | Lost 1 | 2-3 | 5-0 | 0-0 |
| Date | Opponent | Result | Time/Status | Links |
| Sep. 2 | Olivet | W, 27-13 | Final | |
| Sep. 16 | at Adrian | W, 28-7 | Final | |
| Sep. 23 | at Rockford | W, 31-0 | Final | BX |
| Sep. 30 | at Mount St. Joseph * | W, 28-14 | Final | |
| Oct. 7 | Hanover * | W, 13-7 | Final | |
| Oct. 14 | at Manchester * | W, 21-12 | Final | |
| Oct. 21 | Franklin * | L, 37-27 | Final | |
| Oct. 28 | Thomas More | L, 17-7 | Final | |
| Nov. 4 | at Anderson * | W, 16-0 | Final | |
| Nov. 11 | Bluffton * | L, 31-30 | Final | |
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